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HEREDITARY NONPOLYPOSIS COLORECTAL CANCER
Descriptors Found:
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DeCS
Descriptor
English
:
Colorectal Neoplasms, Hereditary Nonpolyposis
Descriptor
Spanish
:
Neoplasias Colorrectales Hereditarias sin Poliposis
Descriptor
Portuguese
:
Neoplasias Colorretais Hereditárias sem Polipose
Synonyms
English
:
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Syndrome
Tree Number:
C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255
Definition
English
:
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of
polyps
, hereditary nonpolyposis
colorectal neoplasms
occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in
mismatch repair
(MMR) genes. It has been subdivided into Lynch
syndrome
I or site-specific colonic cancer, and
LYNCH SYNDROME II
which includes extracolonic cancer.
Indexing Annotation
English
:
DF: HNPCC
History Note
English
:
87
Allowable Qualifiers
English
:
BS
blood supply
BL
blood
CF
cerebrospinal fluid
CI
chemically induced
CH
chemistry
CL
classification
CO
complications
DI
diagnosis
DH
diet therapy
DT
drug therapy
EC
economics
EM
embryology
EN
enzymology
EP
epidemiology
EH
ethnology
ET
etiology
GE
genetics
HI
history
IM
immunology
ME
metabolism
MI
microbiology
MO
mortality
NU
nursing
PS
parasitology
PA
pathology
PP
physiopathology
PC
prevention & control
PX
psychology
RA
radiography
RI
radionuclide imaging
RT
radiotherapy
RH
rehabilitation
SC
secondary
SE
secretion
SU
surgery
TH
therapy
US
ultrasonography
UL
ultrastructure
UR
urine
VE
veterinary
VI
virology
Record Number:
24009
Unique Identifier:
D003123
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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